Research articles


  1.  Yuhui Gong and Gerard Marriott (2020). Bead-based immunocomplex entrapment assays for rapid, sensitive   and multiplexed detection of disease biomarkers with minimal user intervention. ACS Sensors (I2020). ACS Sensors, 5, 1, 180–190

  2.  Natalie Curley,   Daniel Levy,   Mai Do,   Annie Brown,   Zachary Stickney,   Gerard Marriott* and  Biao Lu* (*corresponding authors).  Sequential deletion of CD63 identifies topologically distinct scaffolds for surface engineering of exosomes in living human cells. (2020). Nanoscale.

  3. Dong Tu  Chao‐Nan Xu  Sunao Kamimura  Yoichi Horibe  Hirotaka Oshiro  Lu Zhang  Yoshiharu Ishii  Koji Hyodo Gerard Marriott  Naohiro Ueno  Xu‐Guang Zheng (2020). Ferroelectric Sr3Sn2O7:Nd3+: A New Multipiezo Material with Ultrasensitive and Sustainable Near‐Infrared Piezoluminescence. Advanced Materials

  4. Z. Cheng and G. Marriott. (2019). Multimodality Molecular Imaging. Frontiers in Physics. 7, 177Dong Tu  Chao‐Nan Xu  Sunao Kamimura  Yoichi Horibe  Hirotaka Oshiro  Lu Zhang  Yoshiharu Ishii  Koji Hyodo  Gerard Marriott  Naohiro Ueno  Xu‐Guang ZhengZhang, JC*, Wang, X., Marriott, G*. Xu, CN* (co-corresponding author). Trap-controlled mechanoluminescent materials. Progress in Materials Science (2019) doi:

  5.  MA Do, D Levy, A Brown, G Marriott, B Lu. (2019). Targeted delivery of lysosomal enzymes to the endocytic compartment in human cells using engineered extracellular vesicles. (2019). Scientific reports 9 (1), 1-11

  6. Duong, N., Curley, K., Brown, A., Campanelli, A., Do, MA, Levy, D, Tantry, A., Marriott, G, Lu, B. (2019). Decoy Exosomes as a Novel Biologic Reagent for Antagonizing Inflammation. International Journal of Nanomedicine. In Press

  7. Mu, C., Shi, M., Liu, P., Chen, L., & Marriott, G. Daylight-Mediated, Passive, and Sustained Release of the Glaucoma Drug Timolol from a Contact Lens. ACS central science (2018), 4(12), 1677-1687.

  8. Meyer, C., losacco, J, Stickney, Z., Li, L., Marriott, G. & Lu, B. Pseudotyping exosomes for enhanced protein delivery in mammalian cells. International Journal of Nanomedicine (2017):12 3153–3170

  9.  Kamimura, S., Xu, C-N., Yamada, H., Ooshiro, Y., Tu,D. Marriott, G., Hyodo,I and  Ohno, T. Near-infrared luminescence from double-perovskite Sr3Sn2O7:Nd3+: A new class of probe for in vivo imaging in the second optical window of biological tissue. J. Ceramic Society of Japan (2017). 125 (7), 591-595.

  10. Marriott. G. Engineering platelets for tumour targeting. Aging. (2016). Vol. 8.  doi: 8. 10.18632/aging.101014

  11.  Sun^, T, Kan^, S., Marriott,* G., Chang-Hasnain,* C. High-contrast grating resonators for label-free detection of disease biomarkers.  Scientific Reports (2016). doi:10.1038/srep27482                  ^=equal contribution; *= co-corresponding authors

  12. Dai, L. Gu, N., Chen, BA, Marriott, G.   "Human platelets repurposed as vehicles for in vivo imaging of myeloma xenotransplants"  OncoTarget (2016) DOI: 10.1 8632/oncotarget.8517

  13. Marriott, G. Synthetic and Genetically-encoded Fluorescence Probes for Quantitative Analysis of Protein Hydrodynamics. Perspectives on Fluorescence: A Tribute to Gregorio Weber. Edited by David M. Jameson. (2016). Springer-Verlag.

  14.   Hoepker, AC, Wang, A, LeMarois, A., Suhling, K., A, Yan, Y and Marriott G Genetically encoded sensors of protein hydrodynamics and molecular proximity. PNAS. (2015). doi: 10.1073/pnas.1424021112

  15.  Hoepker, AC, Yan, Y. and Marriott, G. Genetically-encoded sensors of protein hydrodynamics. Oncotarget. (2015). pp16808-16809.

  16. Pereira, J. H., Petchprayoon, C., Hoepker, A. C., Moriarty, N., Fink, S. J., Cecere, G., Paterson, I., Adams, P. D. and Marriott, G. Structural and Biochemical Studies of Actin in Complex with Synthetic Macrolide Tail Analogues. ChemMedChem. (2014), doi: 10.1002/cmdc.201402150

  17. Wu, L.X, Dai, Y. Jiang, X., Petchprayoon, C., Lee, JE, Jiang, T, Yan, Y. and Marriott, G. (2013). High-contrast fluorescence imaging in fixed and living cells using optimised optical switches. PlosOne. [G1] 8(6): e64738. [G2] 

  18. Yan, Y., Petchprayoon, C., Mao, S., & Marriott, G. (2013). Reversible optical control of cyanine fluorescence in fixed and living cells: optical lock-in detection immunofluorescence imaging microscopy. Philosophical Transactions of the Royal Society B: Biological Sciences, 368, 1611 

  19. Wang, Q., Gu, Z Fang, K, Marriott, G, Gu, N (2013). Silver Nanoparticle-Embedded Microbubble as a Dual-Mode Ultrasound and Optical Imaging Probe. ACS applied materials & interfaces 5 (18), 9217-9223

  20. Wang. H., Chalovich. J & Marriott, G. (2012). Structural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: A multi-site Förster resonance energy transfer (FRET) study.  PLoS ONE 7(12): e50420.

  21. Wu, L, Dai, YR and Marriott, G. (2011). Optical Control of Calcium Affinity in a Spiroamido-rhodamine Based Calcium Chelator. (2011). Org. Lett., 13 (8), pp 2018–2021

  22. Yan, Y., Marriott, M.E., Petchprayoon, C. and Marriott, G. (2011). Optical switches: High-contrast imaging in living cells and tissue. Biochemical J. 433 (411–422).

  23. Yan, Y. and Marriott, G. (2011). Optical Manipulation of Protein Activity and Protein Interactions Using Caged Proteins and Optical Switch Protein Conjugates. In: Photo-control of Biological Function. Eds. Chambers, J. and Kramer, R. Elsevier Protocols. Humana Press. pp. 213-231

  24. Petchprayoon, C. and Marriott, G. (2010). Synthesis and spectroscopic characterization of red-shifted spironaphthoxazine optical switch reagents for studies in the living cell. Tetrahedron Letters. doi:10.1016/j.tetlet.2010.10.084 [G3] 

  25. Petchprayoon, C, Yan, Y., Mao, S. and Marriott, G. (2010). Rational design, synthesis and characterization of highly fluorescent optical switches for high-contrast optical lock-in detection (OLID) imaging microscopy in living cells. Bioorganic and Medicinal Chemistry. doi:10.1016/j.bmc.2010.07.015

  26. Petchprayoon, C, and Marriott, G. (2010). Design, synthesis and application of optical switch probes. Current Protocols in Chemical Biology. (DOI: 10.1002/9780470559277. ch100054)

  27. Du, G., Marriott, G. and Yan, Y. (2010). An improved optical lock-in detection method for contrast-enhanced imaging in living cells. Bioinformatics and Biomedical Engineering (ICBBE 2010). (DOI 10.1109/ICBBE. 2010.5516102)

  28. Marriott, G, Mao, S., T. Sakata, Jackson, D. Gomez, T., Aaron, H., Isacoff, EY, Yan, Y. (2008). High contrast imaging based on optical lock-in detection imaging of synthetic and genetically encoded optical switches: PNAS. 105, 17789-17794

  29. Perrins, RD, Cecere, G., Paterson I. and Marriott, G. (2008). Molecular Dissection and Functional Analysis of Reidispongiolide A binding to actin. Chemistry and Biology, 15, 287-294,

  30. Mao, S., Benninger, RKW., Piston, D., Jackson, Easley, C., D. Yan, Y. & Marriott, G. (2008). Optical lock-in detection of FRET using genetically encoded optical switches: High contrast FRET imaging of protein interactions in living cells. Biophysical J. 94, 4515–4524

  31. Fang Jie, Tomoyo Sakata, Gerard Marriott, and Kuni H. Iwasa. (2008). Probing conformational changes of prestin with thiol-reactive optical switches. Biophys. J. BioFAST: June 13, 2008. (DOI:10.1529/biophysj.108.132878)

  32. K. Kerenerit, Z Pincus, M. Allen, EL. Barnhart, G. Marriott, A. Mogilner & JA. Theriot. (2008). Mechanism of shape determination in motile cells. Nature 453, 475 - 480

  33. Welham NV, Marriott G, Tateya I, Bless DM. (2008). Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection. Proteomics. 8(9):1933-44

  34. Wang, H, Mao, S., Chalovich, J. & Marriott, G. (2008). Tropomyosin dynamics in cardiac thin filaments: A multi-site Foerster resonance energy transfer and anisotropy study. Biophysical J. 94. 4358–4369

  35. Sakata, T. Mao, S., Yan Y. & Marriott, G. (2008). Reversible, optical switching of divalent metal ion chelators. Journal of Organic Chemistry. Journal of Organic Chemistry. 73 (1), 227 -233

  36. C. Tanaka,, J. Tanaka, R. Bolland, G. Marriott and T. Higa. (2006). Seragamides A-F, new actin-targeting depsipeptides from the sponge Suberites japonicus Thiele. Tetrahedron. 62, 3536-3542

  37. Petchprayoon C., Asato Y., Higa T., Garcia-Fernandez L.F., Pedpradab S., Marriott G., Suwanborirux K. &Tanaka J. (2006) Four new kabiramides from the Thai sponge, Pachastrissa nux. Heterocycles 69, 447

  38. Welham, NV, Marriott, G*, Bless, DM (2006). Proteomic profiling of rat thyroarytenoid muscle. JSLHR, 49, 671-685. (*corresponding author).

  39. Petchprayoon, C., Khanit, S. Tanaka, J., Yan, Y. and Marriott, G. (2005). Fluorescent Kabiramides: New Probes to Quantify Actin in vitro and in vivo. Bioconjugate Chem. 16 (6), 1382 -1389

  40. Sakata, T., Yan, Y. & Marriott, G. (2005). Optical switching of dipolar interactions on proteins. PNAS. 102, 4759-2764

  41. Humphrey, D., Rajfur, Z., Imperiali, B., Marriott, G., Roy, P., and Jacobson, K. (2005). Application of light-directed activation of caged biomolecules and chromophore-assisted light inactivation to problems in cell motility. In Live Cell Imaging. pp.159-176. Ed. David Spector and Bob Goldman. Cold Spring Harbor Laboratory Press.

  42. Klenchin, V. King, R. Tanaka, J., Marriott, G. and Rayment, I (2005). Structural Basis of Swinholide A Binding to Actin. Chemistry & Biology. 12, 287-291

  43. Lee, H.J., Yan, Y., Marriott, G* & Corn, R. (2005). Quantitative functional analysis of protein interactions on surfaces. J. Physiol (Lond) 2005 563: 61-71

  44. Sakata, T. Yan Y. & Marriott, G. A family of site-selective optical switches. (2005). [G4] J. Organic Chem. 70., 2009 - 2013

  45. Petchprayoon, C., Khanit, S., Miller, R., Sakata, T. and Marriott, G. (2005). Synthesis and biochemical and cellular characterization of a kabiramide C harbouring a pendant amino group. [G5] [G6] J. Natural Product Chemistry. 68. 157 – 161[G7] 

  46. Allingham J., Tanaka, J., Marriott, G & Rayment, I. Stereochemistry of Ulapualide A. (2004). Org. Lett. 6; 597

  47. Tanaka, C., Yamamoto, Y., Otsuka, M., Tanaka, J., Ichiba, T., Marriott, G., Rachmat, R. and Higa, T. (2004). Briarane Diterpenes from Two Species of Octocorals. J. Nat. Prod. 67. 1368-1373.

  48. Tanaka, J., Yan, Y., Choi, J, Bai, J., Klenchin, V.A., Rayment, I and Marriott, G. (2003). Biomolecular mimicry in the actin cytoskeleton: Mechanisms underlying the cytotoxicity of kabiramide C and related macrolides. [G8] PNAS. 100, 13851-13856

  49. Klenchin, V.A., Allingham, J., King, R. Tanaka, J., Marriott, G.* and Rayment, I*. (2003). High-resolution crystal structure of the kabiramide-actin complex.[G9]  Nature Structural Biology. 10 (12). 1058-1063

  50. Yan, Y and Marriott, G. (2003). Analysis of Protein Interactions using Fluorescence Technologies. Curr. Opin. Chem. Biol. 7, 1-6

  51. Schneider, N., Weber, I, Faix, J, Prassler, J., Müller-Taubenberger, A., Köhler, J., Gerisch G. and Marriott, G. (2003). A Lim Protein Involved in the Progression of Cytokinesis and Regulation of the Mitotic Spindle. Cell Motility and the Cytoskeleton 56. 130-139

  52.  J. Wegner, H.J. Lee, G. Marriott and R.M. Corn. (2003). Fabrication of Histidine-Tagged Fusion Protein Arrays for Surface Plasmon Resonance Imaging Studies of Protein-Protein and Protein-DNA Interactions. Anal. Chem. 75(18); 4740-4746.

  53. Marriott, G. and Parker, I. Editor. Biophotonics. Methods in Enzymology. Vols. 360 and 361 (2003).

  54. Marriott, G. Jacobson, K. and Roy, P. Caging proteins through chemical modification. Methods in Enzymology. 360. 274-288 (2003)

  55. Yan, Y and Marriott G. FRET image microscopy and fluorescence polarisation Image Microscopy.[G10]  Methods in Enzymology. Vol 36, 560-582 (2003). [G11] 

  56. Brown, M.T., McBride, K., Baniecki, M., Reich, N., Marriott, G. and Mangel, WF. (2002). Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton. J. Biol. Chem. 277:46298-303.

  57. T Yanagida, E Tamiya, H Muramatsu, P Degenaar, Y Ishii, Y Sako, K Saito, S Ohta-Iino, S Ogawa, G Marriott, A Kusumi, H Tatsumi. (2002). (Near-Field Microscopy for Biomolecular Systems. In Nano-Optics (pp. 191-236). Springer Berlin Heidelberg.

  58. Yan, Y. and Marriott, G. Molecular imaging of the cytoskeleton using GFP-actin. (2002). Progr. Biotech. 22, 25

  59. Faix, H., Lottspeich, F., Mintert, U. and Marriott, G. (2001). Cortexillin I is a key target for Rac1A in signaling pathways that lead to cytokinesis and cell motility. EMBO J. 20, 3705-3715.

  60. J. Tanaka, Marriott, G, Higa, T and Higa, T. (2001). Cacofurans A and B. New Furanoditerpenes from a marine sponge. J. Natural Products. 64; 1468-1470

  61. Roy, P., Rajfur, Z., Jones, D. Marriott, G. & Jacobson, K. (2001). Local Photorelease of caged thymosin b4 in locomoting keratocytes causes cell turning. J. Cell Biology. 153, 1035-104.

  62. Rozelle AL, Machesky LM, Yamamoto M, Driessens MH, Insall RH, Roth MG, Luby-Phelps K, Marriott G, Hall A, Yin HL. (2000). Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol. 10(6):311-320.

  63. Miyata, H, Ohki, K., Marriott, G. Nishiyama, S., Akashi, K. and Kinosita, K. (2000). Cell Deformation Mechanisms Studied with Actin-containing Giant Vesicles, a Cell-mimicking System. In Giant Vesicles. P.L. Luisi and P. Walde editors. John Wiley & Sons.

  64. Defacque H, Egeberg M, Habermann A, Diakonova M, Roy C, Mangeat P, Voelter W, Marriott G, Pfannstiel J, Faulstich H, Griffiths G. (2000). Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J.19(2):199-212

  65. G. Marriott and J. Walker. (1999). Caged proteins and caged peptides. Tr. Plant Sci. 4, 330-334.

  66. Stocker, S., Hiery, M. and Marriott, G. (1999). Phototactic migration of Dictyostelium cells is linked to a new type of gelsolin-related protein. Mol. Biol. Cell  10, 161-78

  67. Usui T. Marriott G. Inagaki M. Swarup G. Osada H. (1999). Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells. J. Biochemistry 125:960-5,

  68. Choidas, A., Jungbluth, A., Sechi, A., Ullrich, A. and Marriott, G. (1998). The suitability and application of a GFP-actin fusion protein for long-term imaging of the organization and dynamics of the cytoskeleton in Mammalian cells. Eur. J. Cell Biol.  77, 81-90.

  69. Prassler, J., Murr, A. Faix, J. and Marriott, G. (1998). Molecular and cellular characterization of a LIM-domain protein from the cytoskeleton of Dictyostelium. Mol. Biol. Cell. 9, 554.

  70. Ottl, J., Gabriel, D. and Marriott, G. (1998). Synthesis, Characterization and Application of a New Class of Photocleavable Heterobifunctional Crosslinking Reagent. Bioconjugate Chemistry. 9, 143.

  71. Marriott, G. (1998).Editor. Caged Compounds. Methods in Enzymology. Volume 291.

  72. Marriott, G, Ottl, J., Heidecker, M. & Gabriel, D. (1998). Caged Proteins. Meth. Enzymol. 291, 95

  73. Marriott, G. and Ottl, J. Photocleavable Crosslinking Reagents. (1998). Meth. Enzymol. 291, 155.

  74. Miyata, H., Kinosita, K. and Marriott, G. (1997). Cooperative Association of Actin Monomers and Crosslinked Actin Oligomers in Filaments. J. Biochemistry. 121, 527-533.

  75. Westphal, M., Jungbluth, A., Mulbauer, B. Heidecker, M., Marriott, G. and Gerisch, G. (1997). Microfilament Dynamics in Motility and Cytokinesis Imaged with GFP-Actin. Curr. Biol. 7, 176.

  76. Prassler, J., Stocker, S., Marriott, G., Heidecker, M., and Gerisch, G. (1997). Interaction of a Dictyostelium Fimbrin with Actin Filaments and Actin-Myosin Complexes. Mol. Biol. Cell. 8, 83.

  77. Marriott, G. and Heidecker, M. (1996). Light-directed Activation of the Actin-Activated ATPase of a Caged Heavy Meromyosin. Biochemistry 35, 3170-3174.

  78. Helms, M.K., Marriott, G., Sawyer, W.H. & Jameson, D.M. (1996). Dynamics and morphology of the in vitro polymeric form of EfTu from E. coli. BBA. 1291, 122-132.

  79. Heidecker, M., Yan-Marriott, Y and Marriott, G. (1995). Fluorescence Resonance Energy Transfer Between Fluorescent Phalloidins on Single Actin Filaments. Biochemistry 34, 11017.

  80. Marriott G (1994). Caged Protein Conjugates and Light-directed Generation of Protein Activity: Photoactivation and Characterization of Caged G-actin. Biochemistry 33, 9092.

  81. Marriott, G., Heidecker M., Diamandis, E. and Yan-Marriott, Y. (1994). Time-resolved Delayed Luminescence Image Microscopy Using Europium-Ion Chelates. Biophysical J. 67, 957.

  82. Marriott, G., Jovin, T. and Yan-Marriott, Y. Synthesis and Spectroscopic Characterization of BBAN: A Thiol-Reactive Phosphorescent Probe. (1994). Analytical Chemistry 66, 1490-1494.

  83. Kinosita, Jr. K., Suzuki N., Ishiwata S., Nishizaka T., Itoh, H., Marriott, G. and Miyata H. (1993). Orientation of Actin Monomers in Moving Actin Filaments. Adv. Exp. Med. Biol. 332:321.

  84. Marriott, G., Miyata, H. & Kinosita, K. Jr. (1992). Photomodulation of the Nucleating Activity of a Photocleavable Crosslinked Actin Dimer. Biochemistry Int. 126, 943-951.

  85. Marriott, G., Clegg, R. M., Arndt-Jovin, D. and Jovin, T. M. (1991). Time-Resolved Imaging Microscopy: Phosphorescence and Delayed Fluorescence. Biophysical Journal. 60, 1374-1387.

  86. Marriott, G., Kirk, Johnsson, N. and Weber, K. (1990). Spectroscopic Studies on the Ca2+-Dependent Lipid Binding Protein p36: The Annexin Repeat as the Ca2+-Binding Site. Biochemistry 29, 7004.

  87. Piston, D., Marriott, G., Clegg, R. M., and Gratton, E. (1989). A Wideband Acousto-Optic Modulator for Frequency Domain Fluorimetry and Phosphorimitry. Rev. Sci. Instrum. 60, 2596.

  88. Jovin, T. M., Marriott, G., Clegg, R. M. and Arndt-Jovin, D. J. (1989). Photophysical Processes Exploited in Microscopy: FRET and Delayed Luminescence. Bunsen-Ges. f. Phys. Chem. 93, 387.

  89. Marriott, G., Zechel, K. and Jovin, T. (1988). Spectroscopic and Functional Characterization of an Environmentally Sensitive Fluorescent Actin Conjugate. Biochemistry 27, 6214.

  90. Johnsson, N., Marriott, G. and Weber, K. (1988). p36, the Major Cytoplasmic Substrate of src Tyrosine Protein Kinase, Binds to the p11 Subunit via an Amphipathic Helix. [G12] EMBO. J. 7, 2435.[G13] 

  91. Gratton, E., Alcala, J. R., Marriott, G. and Prendergast, F. G. (1987). Fluorescence Lifetime Distributions of Single Tryptophan Proteins. In Structure, Dynamics and Function of Biomolecules.

  92. Gratton, E., Alcala, J. R. and Marriott, G. (1985). Rotations of Tryptophan Residues in Proteins. Biochem. Soc. Trans. 14, 835-838. 

  93. Gratton, E., Alcala, J., Marriott, G. and Prendergast, F. (1985). Fluorescence Studies of Protein Dynamics. In Progress and Challenges in Natural and Synthetic Polymer Research.


©2018 by Marriott Lab. Proudly created with