Dr Yuhui Gong
Prof. Gerard Marriott received a BSc (Hons) in Biochemistry from Birmingham University, UK in 1980, and a PhD from the University of Illinois in 1987 under the tutorship of Gregorio Weber, a pioneer in biological spectroscopy. He was awarded prestigious fellowships from the Alexander von Humboldt Stiftung and the Japan Society for the Promotion of Science working with Profs. Thomas Jovin and Kazuhiko Kinosita, respectively. His postdoctoral research led to the introduction and applications of caged proteins and fluorescence lifetime resolved imaging microscopy. As a C3-professor at the Max Planck Institute for Biochemistry in Martinsried he applied caged proteins to address fundamental mechanisms of muscle contraction and cell motility, and he introduced new quantitative and dynamic fluorescence microscope techniques to study structural dynamics of protein complexes associated with force generation in muscle contraction and cell motility.
He was recruited to University of Wisconsin-Madison in 1999 to lead a new biophotonics initiative, and to UC-Berkeley in 2009 where he continues his long standing interest in biosensors and optical microscopy. He has received prestigious awards during his career including a top 10 innovation award from The Scientist magazine for his high-contrast OLID imaging microscopy. He has also has developed new classes of genetically-encoded fluorescent proteins for FRET and FA-imaging for quantitative analysis and imaging of target proteins.
His group has established a new program of research on smart
biomaterials. Early successes include a new class of disposable
contact lens that releases glaucoma drugs during exposures to
natural daylight. In addition his group has recently published
work on novel biomarker sensing platforms
that are specifically designed for at-home diagnostics - these
platforms (schematized in the figure) include
the Immunoassay entrapment assay (ICEA), and the
enzyme-linked ICEA (ELICEA).
Current projects include the development of contact lenses
that will allow individuals to detect and to quantify multiple
disease biomarkers, including diabetes, neurologic disorders
and cancer. In a separate project, his group has developed
a drug-releasing, reversible hydrogel system for long-term
release of ocular drugs to the front of the eye (glaucoma and
Finally the group is developing mechanoluminescence materials (ML) that emit light during mechanical load as sensors for protective head gear in sports, and for in vivo imaging of stress distributions in implantable devices and in vitro models of bone.